Sinopsis
Peter Parker es un joven y tímido estudiante que vive con su tía May y su tío Ben desde la muerte de sus padres. Un día es mordido por una araña que ha sido modificada genéticamente, descubriendo al día siguiente que posee unos poderes poco habituales: tiene la fuerza y agilidad de una araña.
Reparto
Tobey Maguire — Spider-Man / Peter ParkerWillem Dafoe — Green Goblin / Norman OsbornKirsten Dunst — Mary Jane WatsonJames Franco — Harry OsbornCliff Robertson — Ben ParkerRosemary Harris — May ParkerJ.K. Simmons — J. Jonah JamesonJoe Manganiello — Flash ThompsonGerry Becker — Maximilian FargasBill Nunn — Joseph 'Robbie' RobertsonJack Betts — Henry BalkanStanley Anderson — General SlocumRon Perkins — Dr. Mendel StrommMichael Papajohn — CarjackerK.K. Dodds — SimkinsTed Raimi — HoffmanBruce Campbell — Ring AnnouncerElizabeth Banks — Miss BrantJohn Paxton — HousemanTim DeZarn — Philip WatsonTaylor Gilbert — Madeline WatsonRandy Poffo — Bone Saw McGrawLarry Joshua — Wrestling PromoterTimothy Patrick Quill — Wrestling Arena GuardLisa Danielle — Bone-etteNatalie T. Yeo — Bone-etteErica D. Porter — Bone-etteKristen Davidson — Bone-etteJason Padgett — Flash's CronyShan Omar Huey — TeacherSally Levi — Girl on BusEvan Arnold — DoctorJill Sayre — NurseJim Ward — Project CoordinatorDavid Holcomb — Test PilotOctavia Spencer — Check-In GirlBrad Grunberg — HecklerShane Habberstad — Little BillyDeborah Wakeham — Billy's MomRachael Bruce — Times Square ChildMackenzie Bryce — Times Square ChildJulia Barrie — Times Square ChildMacy Gray — Macy GrayMyk Watford — Cop at FireBill Calvert — FiremanSylva Kelegian — Mother at FireKristen Marie Holly — Young Lady at FireAjay Mehta — CabbiePeter Appel — CabbieScott Spiegel — Marine CopMatt Smith — Cop at CarjackingSara Ramirez — Cop at CarjackingLucy Lawless — Punk Rock GirlJayce Bartok — Subway GuitaristMaribel González — Lady DogwalkerAmy Bouril — Office LadyJoseph D'Onofrio — Opinionated CopJim Norton — Surly Truck DriverCorey Mendell Parker — Chaperone in TramAshley Edner — Girl in TramWilliam Joseph Firth — Boy in TramAlex Black — Boy in TramLaura Gray — Tram Group MotherJoe Virzi — New Yorker on BridgeMichael Edward Thomas — New Yorker on BridgeJeanie Fox — New Yorker on BridgeRobert Kerman — Tugboat CaptainStan Lee — Man in Fair (uncredited)Una Damon — Lab Tour Guide (uncredited)Rick Avery — Cop (uncredited)Peter Aylward — Colonel (uncredited)Jillian Clare — Crying Girl in Tram (uncredited)Chris Coppola — Kyle (uncredited)Jesse Heiman — Spectator at School Fight (uncredited)Leroy Patterson — World Unity Festival Attendant (uncredited)Benny Urquidez — Mugger (uncredited)Scott L. Schwartz — Screaming Wrestler (uncredited)Jophery C. Brown — Chef (uncredited)Brian J. Williams — Young Thug #2 (uncredited)Mark De Alessandro — Cop (uncredited)Tia Dionne Hodge — Uptown Woman (uncredited)Loren Janes — Board of Directors Member (uncredited)Andray Johnson — Balkan's Aide (uncredited)Martin Pfefferkorn — Thug on 8x10 (uncredited)Tammi Sutton — Street Vendor (uncredited)Lindsay Thompson — Mary Jane's Friend (uncredited)Sean Valla — Boat Light Man (uncredited)Pete Macnamara — Pentagon Officer (uncredited)Al Goto — Cop (uncredited)Joni Avery — Cop (uncredited)Sam Raimi — Popcorn Thrower (uncredited)Craig 'Radio Man' Castaldo — Man with Bike (uncredited)Lou Torres — Enrique